Introduction

Genetic testing is characterized by supporters as the future of food medicine, but the sciences are in their early childhood. Medicines made specifically for a person’s genome is called precision medicine, this is to do with what we eat everyday.

Nutrigenomics is the application of genomic analyses to examine the interactions of diet affecting human health, illness and disease . Many websites are now talking about the relation between nutrigenomics, dna, gene, testing and diet. The study of human reaction to nutrition and its influence on gene expression, biochemical, metabolic and health promotion .

Nutrition research usually focuses on preventive measures, trying to identify which nutrients or food increases or reduces the risk of disease and damages to the human body .

Traditionally, biomarkers relating to the occurrence of diseases or organs have been used to determine the impact, but it is necessary to determine the changes of phenotype, which are very closely or in the healthcare sector ( Ben Van Omen 2008 ) and has focused primarily on the shortcomings of nutrients and the relationship between diet and health .

Current scientists are focused on understanding the nutritional influence of the organism’s metabolism and maintaining its internal balance, and the regulation has an impact on the diet of related diseases ( Ordovas J, 2004 ) and provides a strong and outgoing approach to break down the effects of a health-related diet.

All natural chemicals occur in foods change the molecular expressions of gene data in each person, this is known as gene expression. Nutrigenomics scientists hope to take advantage of the genetic tests to direct “personalised nutrition” .In addition, present molecules in contaminated foods may cause poisonous metabolite species that may interact with DNA, change their structure and cause mutations .

Examples

Today, cardiovascular disease, obesity, cancer and diabetic are 35 million people worldwide . Lifestyle factors such as diet and physical activity are still recognised to play a significant role in the growth and progress of overweight and co-morbidity, there is, however, a caveat, there is increasing evidence (obviously) that genes have a great impact on how some people are more tended towards obesity and co-morbidity.

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Nutrigenomics therefore can assist with the handling of overweight and co-morbidity, and other diseases.

Patients with a specific genetic combination can all indicate that a certain diet makes their symptoms of disease worse .

In Europe, such chronic disease is the 70 percent of all deaths, and the number is estimated to increase by 80 percent by 2030 .

For example, Inflammatory bowel disease ( IBD ) is often present in more than a single family .

Long-term deviation of mineral retention or loss can be discovered in hair, and most hair concentrations are considerably higher than in the blood serum .

While magnesium can regulate A series of genes related to metabolism and demonstrates positive effects on some metabolic paths are related to the evolution of genetic expressions ( Chacko, 2011 ) and magnesium supplementation has been related to A decrease in c-peptide levels, A marker of increased insulin sensitivity .

In nutrition research, the transcriptions can help to provide information about the mechanism or the underlying impact of a certain nutrients or diets .

There is a growing field of functional medical and food, and a portion of the continuous move to increase the personalisation of health care .

New research and study areas include nanotechnology, biological recognition, nutrition and innovation in the field of study .

More examples:

-Gamma ppar is regarded as one of the main regulators of the citatopoeia differentiation process in the process of fatty genesis .

 

-Mitochondria-dense brown fat ( BAT ) is specialized in allowing non-shaking thermogenesis .

-Similarly, the intake of fibres has been associated with reducing the risk of breast cancer, mainly by reducing the proliferation of the ducation of cell and NAF turnover, and possibly by inhibiting intestinal absorption .

-Low-density lipoprotein,” bad” cholesterol levels are linked to the risk of cardiac illness .

Nutrigenomics and Autism

Probably will write more on this topic when I understand it more. Alot of factors can switchs genes on and off changing their expressions, just because someone has a gene doesn’t mean it is expressed. The polymorphisms most associated with autism is the Methyltetrahydrofolate reductase (MTHFR). This is an enzyme pivotal in methylation.

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It is the metabolism of folic acid to 5-methylfolate, part of a complex process, This disruption may be causing increases oxidative stress due to decreased plasma levels of cysteine, gluthatione and the ratio of reduced to oxidised gluthathione, these all affect brain development and neurotransmitter balances. These are imbalances in polymorhisms of Folate, Bipterin and Transsulfuration cycles.

For a detailed break down check out this link.