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How to Get Oxytocin Orgasm? – Research Summary for both Men and Women

Posted by Anonymous on October 11, 2016  /   Posted in Khemcorp Originals, Oxytocin

Can Oxytocin Help Achieving Orgasms or Make Them Better?

Using Oxytocin to trigger Orgasms (Oxytocin Orgasm) for both men and women is a topic of research we get asked about now and again.

The question is what is the science behind the possibility of administrated exogenous Oxytocin to improve orgasms? Is it even possible?

We are going to look at the facts. Preliminary research seems positive, but it’s certainly not anywhere near as researched as Oxytocin for autism.

Oxytocin works very differently in men and women (mechanically you can imagine), so I will separate them into two sections respectively. Finally, the administration of Oxytocin will come after.

 

The Role Oxytocin Plays in Sex and Orgasm

I’m pretty sure, everybody has a general idea of what Oxytocin is, but we should state some obvious points for people who don’t know:

Oxytocin is the love hormone, it is released before and during sex (and probably before too). It is released in the brain to bond and facilitate individuals together, producing a warm lovely 1/4 MDMA type feeling. The circuits are complicated of course and tied with other neurotransmitter pathways such as Dopamine and Serotonin. SSRI anti-depressants probably make significant alterations in these delicate circuits powering the feeling of sex and orgasms. The Serotonin circuit is responsible for the actual synaptic processing of bonding and sex, this explains why SSRI exceedingly cause sexual dysfunction sometimes even permanent.

Deep within the brain Oxytocin is produced by the hypothalamus, the deep limbic system of the brain, it is then released into the blood via the pituitary gland, and to other parts of the brain and spinal cord, where is binds to Oxytocin receptors to influence behavior and physiology.

Oxytocin also certainly plays a part in sexual arousal, correlated with the positive feelings of Dopamine.

 

What the Research Says – Could Oxytocin be Used to Trigger or Raise Orgasms?

One study published not long ago has found a very explicit link between the increase of feelings of orgasms after administration of Oxytocin in humans, it is important to know that the increase was not godly, the orgasms were better but they did not put people into a love-sex-fest.

Rats given Oxytocin get sexual arousal, they get both an erection and an increase in dopamine in an area of the brain called nucleus accumbens, an area associated with being motivated to do shit (basically). It also happens to be the area that gets hit when people do cocaine, and as you can imagine if it’s good cocaine (which probably you haven’t ever tried unless you really got the real stuff from the southern continents) – it feels really good. And of course sex feels great, now you know why – because of Oxytocin.

We shouldn’t jump ahead though because there is absolutely no reason to believe we can trigger the entire experience with an administration of Oxytocin,   What we could probably do is “augment” the system, though we need to know what we are working on, so definitely when it comes to sex Men and Women have their differences!

Oxytocin in Men

So we know Oxytocin is an important part of sexual arousal, we don’t know everything about the brain, but we certainly know there are LOTS of receptors for Oxytocin in the penis, especially in the corpus cavernosa, the long tubes that tank full of blood during an erection/boner/hard-on . I’m pretty sure most guys are really uncomfortable with the fact that their dong is just a pile of fragile blood tubes that get filled up. I have no idea why nature designed the penis to have zero protection at all…

Certainly, the fragility of the penis is one of the reasons why erectile dysfunction is such a common problem with men, especially once pass the age of 30, or premature ejaculations and other issues.

So on the topic of erectile dysfunction. Rats given Oxytocin do get an erection, but are the effects receptors working in the brain or in the penis? It would appear to be in the brain, via dopamine, however, this was by injection directly into the brain!:

Oxytocin injected into these areas increases glutamatergic neurotransmission in the ventral tegmental area. This, in turn, activates mesolimbic dopaminergic neurons, leading to penile erection. These results provide evidence that the ventral subiculum and the posteromedial cortical nucleus of the amygdala participate in a neural circuit that controls not only the consummatory aspects of sexual behaviour (e.g. penile erection and copulatory performance), but also its motivational/reward aspects, confirming a key role of oxytocin and dopamine in these processes.

Oxytocin injected into the ventral subiculum or the posteromedial cortical nucleus of the amygdala induces penile erection and increases extracellular dopamine levels in the nucleus accumbens of male rats.
Melis MR1, Succu S, Sanna F, Boi A, Argiolas A.n
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria, Monserrato, Cagliari, Italy. mrmelis@unica.itIntranasal Oxytocin doesn’t appear to help:

Intranasal OXT administration did not alter “classical” parameters of sexual function, such as sexual drive, arousal or penile erection and lubrication.

Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples.
Behnia B1, Heinrichs M2, Bergmann W1, Jung S1, Germann J2, Schedlowski M3, Hartmann U1, Kruger TH4.
Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg Strasse 1, D-30625 Hanover, Germany.Oxytocin in Women

Intranasal Oxytocin does increase the intensity of the orgasm for both men and women:

According to HLM analysis, OXT increased the intensity of orgasm, contentment after sexual intercourse and the effect of study participation. According to ANOVA analysis, these effects were more pronounced in men. Men additionally indicated higher levels of sexual satiety after sexual intercourse with OXT administration. Women felt more relaxed and subgroups indicated better abilities to share sexual desires or to empathize with their partners.

Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples.
Behnia B1, Heinrichs M2, Bergmann W1, Jung S1, Germann J2, Schedlowski M3, Hartmann U1, Kruger TH4.
Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg Strasse 1, D-30625 Hanover, Germany.Oxytocin in Women

This doesn’t, however, give any information regarding men who have difficulty reaching orgasm. A research piece suggests that Oxytocin can indeed treat male anorgasmia, however, it was used DURING intercourse when ejaculation was saught. This was indeed also intranasal Oxytocin, but obviously would be fairly inconvenient for technical reasons, and this was only based on one patient:

Oxytocin was administered using a nasal spray intracoitally because of its ultra-short half-life. Results. Oxytocin was effective in restoring ejaculation. Conclusions. A case of treatment-resistant male anorgasmia was successfully treated with intracoital administration of intranasal oxytocin.

Male anorgasmia treated with oxytocin.
Ishak WW1, Berman DS, Peters A.
1Cedars-Sinai Medical Center-Psychiatry, Los Angeles, CA 90048, USA. waguih.ishak@cshs.org

Oxytocin in Women

Estrogen enhances Oxytocin meaning women tend to have higher levels of Oxytocin effects with it, which is why they respond far more to touch, emotions and body language than men. Enhanced Oxytocin is also the reason why women have a “tend and befriend” response to stress, versus the fight or flight response to stress found in men.

The strength of the orgasm is directly correlated with the amount of Oxytocin, as well as the sexual arousal in women. Oxytocin also fluctuates, being in the highest during the ovulatory phase.

As Oxytocin and Estrogen are explicitly linked especially in females, its no surprise that increasing Oxytocin increases female sexual behavior.

Elucidating the behavioral effects of oxytocin has been facilitated by its profound regulation by estrogen in discrete brain areas and its subsequent role in estrogen-dependent responses. For example, female sexual behavior is estrogen dependent, estrogen markedly increases oxytocin binding in the ventromedial nucleus of the hypothalamus and infusion of oxytocin in this brain area increases female sexual behavior.

Estrogen modulation of oxytocin and its relation to behavior.
McCarthy, Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA.

Intranasal Oxytocin does increase the intensity of the orgasm women as well, interesting to note that feeling more relaxed is often the barrier for women to achieving orgasm or not, so this could be more useful for women than for men:

According to HLM analysis, OXT increased the intensity of orgasm, contentment after sexual intercourse and the effect of study participation. According to ANOVA analysis, these effects were more pronounced in men. Men additionally indicated higher levels of sexual satiety after sexual intercourse with OXT administration. Women felt more relaxed and subgroups indicated better abilities to share sexual desires or to empathize with their partners.

Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples.
Behnia B1, Heinrichs M2, Bergmann W1, Jung S1, Germann J2, Schedlowski M3, Hartmann U1, Kruger TH4.
Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg Strasse 1, D-30625 Hanover, Germany.Oxytocin in Women

Women are by far more complicated and varied than men when it comes to “achieving orgasm”, for some women it’s easy for others it never happens, what triggers orgasm for women differentiate from woman to woman as well, so the problem cannot be broken down mechanically as we could with men.

That said, empathy, bonding, and relaxation are all very important parts of how good sex is and how good the orgasm is for women, so its probably not preposterous to propose that increasing Oxytocin levels artificially in both the brain and peripherally would likely increase the chances of orgasms happening.

A study in 2015 certainly concludes that Intranasal Oxytocin helps with female sexual dysfunction in premenopause and postmenopause:

CONCLUSION(S): Long-term intranasal oxytocin and placebo administration both improved sexual function and symptoms of depression in women over time with no treatment, sequence (placebo first/second), or interaction effect.

Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial.
Muin DA1, Wolzt M2, Marculescu R3, Sheikh Rezaei S2, Salama M4, Fuchs C2, Luger A5, Bragagna E6, Litschauer B2, Bayerle-Eder M7.
1Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.

On the other hand, the science of why some women can’t achieve orgasm or get pleasure from sex is well beyond the scope of this article, and whichever company figures it out will be very rich. Certainly, I think the fact that SSRI’s also affect women’s sex life negatively may provide a hint that the Serotonin system is also really involved in the activity for women.

Oxytocin Administration Method for Orgasm?

There is a difference between naturally generated Oxytocin and exogenous Oxytocin, in that administrated Oxytocin, whether its a nasal spray or injection may not create the effects naturally produced Oxytocin can. We know about the ROLE of Oxytocin receptors, but the question is whether we can activate those receptors or not using something like a nasal spray. We know we can, but we don’t know whether it is at a level where it can solve sexual dysfunction.

The circuits are complex and beyond our understanding, also due to various cascades and chemical transport issues, it’s safe to assume that exogenous Oxytocin will be unable to trigger the exact mechanisms that are triggered naturally.

I did not think intranasal Oxytocin would work, instead, I had thought it would make sense for sublingual to put Oxytocin in the peripheral network, however, the research points to the activity of Oxytocin triggering orgasms mainly in the brain, primarily the Amygdala, therefore under this understanding. Intranasal is probably the ONLY way to get it into the brain. Oxytocin does not pass the blood-brain barrier.

I think the chances of Oxytocin helping erectile dysfunction is low, it may help create sexual excitement for men, but the only study is a study where it was injected directly into the brain. I think the chances of intranasal Oxytocin reaching those levels is pretty slim. It may very well solve sexual dysfunction for some people, but the complexity of sexual dysfunction in systems from Serotonin to Dopamine suggests that Oxytocin is only a part of the puzzle.

That being said. We think there is a pretty large body of evidence suggesting that Oxytocin intranasally can certainly improve the intensity of orgasms (oxytocin orgasm), the quality of sex and attraction, which makes complete sense given it is the “love hormone”.

– Khemcorp

Research References

Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial.
Muin DA1, Wolzt M2, Marculescu R3, Sheikh Rezaei S2, Salama M4, Fuchs C2, Luger A5, Bragagna E6, Litschauer B2, Bayerle-Eder M7.
Author information
1Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.

Archives of Sexual Behavior
February 1994, Volume 23, Issue 1, pp 59–79
Relationships among cardiovascular, muscular, and oxytocin responses during human sexual activityAuthors
Authors and affiliations
Marie S. CarmichaelValerie L. WarburtonJean DixenJulian M. Davidson

Estrogen modulation of oxytocin and its relation to behavior.
McCarthy MM1.
Author information
1Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA.

Oxytocin injected into the ventral subiculum or the posteromedial cortical nucleus of the amygdala induces penile erection and increases extracellular dopamine levels in the nucleus accumbens of male rats.
Melis MR1, Succu S, Sanna F, Boi A, Argiolas A.
Author information
1Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria, Monserrato, Cagliari, Italy. mrmelis@unica.it

Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples.
Behnia B1, Heinrichs M2, Bergmann W1, Jung S1, Germann J2, Schedlowski M3, Hartmann U1, Kruger TH4.
Author information
1Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg Strasse 1, D-30625 Hanover, Germany.

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