Posted by Anonymous on August 04, 2016  /   Posted in Uncategorized

Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.

Proglumide’s CCK action has been linked in many papers to being able to potentiate, reverse and prevent opiate tolerance.


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