Category Archives: Reverse Tolerance

  • Kratom Potentiation Guide

    Thanks to  the guys at  KratomEye for these suggestions for Kratom potentiation. – Black Seed Oil (cumin seed) – Hordenine (very minute amounts, 5 – 20mg, even. MAO-B inhibitor – works great if you don’t use too much) – Tribulus Terrestris...
  • Memantine Experiences for Drug Tolerance of all Kinds

    Memantine the Unknown Drug Tolerance Prevention Chemical Memantine has had been a well kept secret for drug tolerance prevention. Over the years many people have toyed with it hoping to use it to abuse recreational drugs and not develop tolerance, this...
  • Where Medical Institutions End and Brain Hacking Begins

    Anyone who is not a neurotypical – be it brain damaged from natural cerebral disasters, degenerative diseases or born neuro dysfunctional and different. Knows that medical institutions have a severe limitation when it comes to addressing problems of the mind. Or...
  • Memantine Reversing Nicotine Tolerance – Research

    Article is work in progress. I guess since NMDA receptors have such a role to play in drug tolerance, it isn’t exactly surprising that they seen to attenuate tolerance for alot of other types of drugs as well. Daily treatment for...
  • Memantine Research Summary Explained – The Basics

    Memantine Research Summary Explained – The Basics What is Memantine? Memantine is a novel unique drug that acts on the glutamatergic system by blocking NMDA Receptors, it is mainly prescribed for treating Alzheimer’s disease. Its effects for Alzheimer’s are actually questionable...
  • Success Story: Cycling Between Proglumide, Memantine and

    Very interesting reading. I have been quite successful at reducing my dosage thanks to Proglumide, Memantine and Agmatine (I never had the time and patience to try the low dose of Naltrexone however I had such succes with the rest it...
  • Proglumide Reversing Opiate Tolerance – A Compreh

    Article is work in progress. Link to the first article here :  Proglumide Summary  A second comprehensive review of patent and medical literature for Opiate Potentiation Why are you revisiting Proglumide? Research is never complete, we have had a lot of...
  • Why is drug tolerance prevention and reversal more impor

    In the observable pharmaceutical industry, there are two trends that are unfavourable. The first is the number of new chemical entities (what is required for high profit margin patents) are hitting a wall. They are running out of useful substrates that...
  • Memantine Dosage and Titration for Drug Tolerance and AD

    Short Term Effects on Tolerance Anecdotally, Memantine has possibly immediete effects on opiate and amphetamine tolerance. In these mice, the co-administration of memantine and MRZ 2/579, but not dextromethorphan, resulted in the reversal of morphine tolerance. In experiment 3, memantine and...
  • Herbal Supplements that Help Dealing with Opiate Toleran

    Hi All, After positive feedback from some of our customers as well as some reorders. I thought I’d post some suggestions regarding some supplements that other experienced has helped them deal with tolerance reduction and withdrawal. I will update this post...