Short Term Effects on Tolerance Anecdotally, Memantine has possibly immediete effects on opiate and amphetamine tolerance. In these mice, the co-administration of memantine and MRZ 2/579, but not dextromethorphan, resulted in the reversal of morphine tolerance. In experiment 3, memantine and MRZ 2/579 (10 mg/kg) inhibited the acute antinociceptive effect of morphine, but dextromethorphan did […]

Hi All, After positive feedback from some of our customers as well as some reorders. I thought I’d post some suggestions regarding some supplements that other experienced has helped them deal with tolerance reduction and withdrawal. I will update this post with research when I have the time: So here is a list of stuff […]

Here are some comments we sourced from over the internet: I took ONE 200mg tab of proglumide 8 days ago and my tolerance is still drastically lower. I cant believe it. I went from taking 60-90 mg of oxy at a time to 15 mg at a time However now I am experiencing significant anxiety because I am still […]